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The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study

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Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid peroxidation) and cancer or mortality outcomes. This investigation was based on a German, popula...

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Bibliographic Details
Main Authors: Gao, Xin (Author) , Burwinkel, Barbara (Author) , Holleczek, Bernd (Author) , Brenner, Hermann (Author) , Schöttker, Ben (Author) , Xuan, Yang (Author)
Format: Article (Journal)
Language:English
Published: 24 January 2019
In: Clinical epigenetics
Year: 2019, Volume: 11, Issue: 1
ISSN:1868-7083
DOI:10.1186/s13148-018-0604-y
Online Access:Verlag, Volltext: http://dx.doi.org/10.1186/s13148-018-0604-y
Verlag, Volltext: https://doi.org/10.1186/s13148-018-0604-y
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Author Notes:Xīn Gào, Yan Zhang, Barbara Burwinkel, Yang Xuan, Bernd Holleczek, Hermann Brenner and Ben Schöttker
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Summary:Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid peroxidation) and cancer or mortality outcomes. This investigation was based on a German, population-based cohort with linkage to cancer and mortality registry data (2000-2016).
Item Description:Gesehen am 28.02.2019
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-018-0604-y

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