Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate kinase deficiency natural history study
Pyruvate kinase (PK) deficiency is the most common red cell glycolytic enzyme defect causing hereditary non-spherocytic hemolytic anemia. Current treatments are mainly supportive and include red cell transfusions and splenectomy.[1][1] Regular red cell transfusions are known to result in iron
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2019
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| In: |
Haematologica
Year: 2019, Volume: 104, Issue: 2, Pages: e51-e53 |
| ISSN: | 1592-8721 |
| DOI: | 10.3324/haematol.2018.196295 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.3324/haematol.2018.196295 Verlag, Volltext: http://www.haematologica.org/content/104/2/e51 
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| Author Notes: | Eduard J. van Beers, Stephanie van Straaten, D. Holmes Morton, Wilma Barcellini, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, Satheesh Chonat, Janet L. Kwiatkowski, Jennifer A. Rothman, Mukta Sharma, Ellis J. Neufeld, Sujit Sheth, Jenny M. Despotovic, Nina Kollmar, Dagmar Pospíšilová, Christine M. Knoll, Kevin Kuo, Yves D. Pastore, Alexis A. Thompson, Peter E. Newburger, Yaddanapudi Ravindranath, Winfred C. Wang, Marcin W. Wlodarski, Heng Wang, Susanne Holzhauer, Vicky R. Breakey, Madeleine Verhovsek, Joachim Kunz, Melissa A. McNaull, Melissa J. Rose, Heather A. Bradeen, Kathryn Addonizio, Anran Li, Hasan Al-Sayegh, Wendy B. London, Rachael F. Grace |
| Summary: | Pyruvate kinase (PK) deficiency is the most common red cell glycolytic enzyme defect causing hereditary non-spherocytic hemolytic anemia. Current treatments are mainly supportive and include red cell transfusions and splenectomy.[1][1] Regular red cell transfusions are known to result in iron |
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| Item Description: | Gesehen am 28.02.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1592-8721 |
| DOI: | 10.3324/haematol.2018.196295 |