Direct photoassisted α-Trifluoromethylation of aromatic Ketones with trifluoroacetic Anhydride (TFAA)
Direct α-Trifluoromethylation of acetophenone derivatives was achieved by using trifluoroacetic anhydride (TFAA) as the trifluoromethyl source and pyridine-N-oxide (Py−O) as activator and oxidant under visible light irradiation and tris-(2,2′-bipyridine)ruthenium(II) hexafluorophosphate (Ru(bpy)3(PF...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
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| In: |
Advanced synthesis & catalysis
Year: 2019, Volume: 361, Issue: 4, Pages: 720-724 |
| ISSN: | 1615-4169 |
| DOI: | 10.1002/adsc.201801305 |
| Online Access: | Resolving-System, Volltext: http://dx.doi.org/10.1002/adsc.201801305 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.201801305 
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| Author Notes: | Somnath Das, A. Stephen K. Hashmi, and Thomas Schaub |
| Summary: | Direct α-Trifluoromethylation of acetophenone derivatives was achieved by using trifluoroacetic anhydride (TFAA) as the trifluoromethyl source and pyridine-N-oxide (Py−O) as activator and oxidant under visible light irradiation and tris-(2,2′-bipyridine)ruthenium(II) hexafluorophosphate (Ru(bpy)3(PF6)2) as the photocatalyst. Different acetophenone derivatives could be converted to the corresponding α-CF3 derivatives with high selectivity. Extensive mechanistic investigation revealed the formation of vinyl trifluoroacetate as the key intermediate for this transformation. |
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| Item Description: | First published: 03 December 2018 Gesehen am 01.03.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1615-4169 |
| DOI: | 10.1002/adsc.201801305 |