C-reactive protein 2 days after laparoscopic gastric bypass surgery reliably indicates leaks and moderately predicts morbidity
BackgroundThe aim of the present study was to evaluate whether serum C-reactive protein (CRP) is a useful predictor of early post-operative complications, particularly of intestinal leaks after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery.MethodsThe present study was a retrospective analysi...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 April 2012
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| In: |
Journal of gastrointestinal surgery
Year: 2012, Volume: 16, Issue: 6, Pages: 1128-1135 |
| ISSN: | 1873-4626 |
| DOI: | 10.1007/s11605-012-1882-x |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s11605-012-1882-x Verlag, Volltext: https://doi.org/10.1007/s11605-012-1882-x 
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| Author Notes: | Rene Warschkow, Ignazio Tarantino, Patrick Folie, Ulrich Beutner, Bruno M. Schmied, Philipp Bisang, Bernd Schultes, Martin Thurnheer |
| Summary: | BackgroundThe aim of the present study was to evaluate whether serum C-reactive protein (CRP) is a useful predictor of early post-operative complications, particularly of intestinal leaks after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery.MethodsThe present study was a retrospective analysis of a prospectively maintained database with 809 patients who underwent LRYGB from 2002 until 2011. For 410 of these patients, at least one CRP measurement within the first seven post-operative days was available. The diagnostic value was determined by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.ResultsForty-nine of 410 patients (12.0 %; 95 % confidence intervals [95 % CI], 9.2-15.5 %) developed surgery-related complications. Leaks occurred in 17 patients (4.1 %; 95 % CI, 2.6-6.5 %) at a median of 5 days after surgery. CRP levels 2 days after surgery showed the highest diagnostic value for post-operative complications (AUC, 0.74; 95 % CI, 0.60-0.89). Sensitivity was 0.53 (95 % CI, 0.31-0.74) and specificity was 0.91 (95 % CI, 0.79-0.96) on day 2 (cutoff level, 229 mg/l). The sensitivity for intestinal leaks was 1.00 (95 % CI, 0.51-1.00).ConclusionCRP on post-operative day 2 is a valuable predictor of post-operative complications, in particular intestinal leaks. Radiological imaging studies for intestinal leaks could be restricted to patients with CRP values exceeding 229 mg/l. |
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| Item Description: | Gesehen am 05.03.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1873-4626 |
| DOI: | 10.1007/s11605-012-1882-x |