Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differen...

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Hauptverfasser: Lee, Catherine (VerfasserIn) , Zapatka, Marc (VerfasserIn) , Pfister, Stefan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 18 January 2019
In: Nature Communications
Year: 2019, Jahrgang: 10
ISSN:2041-1723
DOI:10.1038/s41467-018-08269-5
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1038/s41467-018-08269-5
Verlag, Volltext: https://www.nature.com/articles/s41467-018-08269-5
Volltext
Verfasserangaben:Catherine Lee, Vasilisa A. Rudneva, Serap Erkek, Marc Zapatka, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Alexandra Garancher, Jessica M. Rusert, Ozlem Aksoy, Robin Lea, Helai P. Mohammad, Jianxun Wang, William A. Weiss, H. Leighton Grimes, Stefan M. Pfister, Paul A. Northcott & Robert J. Wechsler-Reya
Beschreibung
Zusammenfassung:Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.
Beschreibung:Gesehen am 06.03.2019
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-018-08269-5