Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differen...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 January 2019
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| In: |
Nature Communications
Year: 2019, Volume: 10 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-08269-5 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/s41467-018-08269-5 Verlag, Volltext: https://www.nature.com/articles/s41467-018-08269-5 
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| Author Notes: | Catherine Lee, Vasilisa A. Rudneva, Serap Erkek, Marc Zapatka, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Alexandra Garancher, Jessica M. Rusert, Ozlem Aksoy, Robin Lea, Helai P. Mohammad, Jianxun Wang, William A. Weiss, H. Leighton Grimes, Stefan M. Pfister, Paul A. Northcott & Robert J. Wechsler-Reya |
| Summary: | Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors. |
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| Item Description: | Gesehen am 06.03.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-08269-5 |