Cancer stem cells: novel concepts and prospects for tumor therapy
Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem...
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| Other Authors: | , , |
| Format: | Conference Paper Edited Volume |
| Language: | English |
| Published: |
Berlin, Heidelberg
Springer-Verlag Berlin Heidelberg
2007
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| Series: | Springer Series on Biofilms
2006/5 Ernst Schering Foundation Symposium Proceedings 2006/5 SpringerLink Bücher |
| In: |
Ernst Schering Foundation symposium proceedings (2006,5)
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| Volumes / Articles: | Show Volumes / Articles. |
| DOI: | 10.1007/978-3-540-70853-7 |
| Subjects: | |
| Online Access: | Verlag, Volltext: https://doi.org/10.1007/978-3-540-70853-7 Resolving-System, lizenzpflichtig, Volltext: http://dx.doi.org/10.1007/978-3-540-70853-7 Cover: https://swbplus.bsz-bw.de/bsz283445165cov.jpg 
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| Author Notes: | O. D. Wiestler, B. Haendler, D. Mumberg, eds. |
| Summary: | Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer. Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study end points. |
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| Item Description: | Includes bibliographical references |
| Physical Description: | Online Resource |
| ISBN: | 9783540708537 |
| DOI: | 10.1007/978-3-540-70853-7 |