Voltage-gated sodium channels: structure, function and channelopathies
Intro -- Preface -- Contents -- Part I: Evolution of Voltage-Gated Sodium Channels -- Evolutionary History of Voltage-Gated Sodium Channels -- 1 Introduction -- 2 Structural Outlines of Voltage-Gated Sodium Channels -- 3 Historical Origin of Voltage-Gated Sodium Channels and Their Related Proteins -...
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| Other Authors: | |
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| Format: | Book/Monograph |
| Language: | English |
| Published: |
Cham
Springer
2018
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| Series: | Handbook of experimental pharmacology
246 |
| In: |
Handbook of experimental pharmacology (246)
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| Volumes / Articles: | Show Volumes / Articles. |
| Online Access: | Verlag, Volltext: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=5413864
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| Author Notes: | editor Mohamed Chahine (CERVO Brain Research Center, Institut Universitaire en Santé Mentale, Quebec, Canada) |
| Summary: | Intro -- Preface -- Contents -- Part I: Evolution of Voltage-Gated Sodium Channels -- Evolutionary History of Voltage-Gated Sodium Channels -- 1 Introduction -- 2 Structural Outlines of Voltage-Gated Sodium Channels -- 3 Historical Origin of Voltage-Gated Sodium Channels and Their Related Proteins -- 4 Evolution of Bilaterians and Voltage-Gated Sodium Channel Proteins -- 5 Voltage-Gated Sodium Channels in Chordates -- 6 Evolution of NaV1 Channels in Vertebrates -- 7 Independent Gene Duplications of NaV1 in Teleosts and Amniotes -- 8 Concluding Remarks -- References -- Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits -- 1 Sodium Channel Basics -- 2 VGSC and Human Disease -- 3 β-Subunit Homology from the Perspective of Primary Sequence -- 4 Evolutionary History of Beta-Subunits -- 5 Structural Features and Regions of Sequence Conservation -- References -- Part II: The Structural Basis of Sodium Channel Function -- Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective -- 1 Introduction -- 2 The Voltage-Sensing Module -- 2.1 The Excitable Membrane and the Voltage Sensor -- 2.2 A Conserved Mechanism of Activation -- 3 The Selectivity Filter: From Symmetry to Asymmetry -- 4 Inactivation Evolved from Bacterial to Eukaryotic Sodium Channels -- 4.1 Slow Inactivation of Eukaryotic Sodium Channels -- 4.2 Studies of Slow Inactivation of Bacterial Sodium Channels -- 4.3 Evolution of Fast Inactivation in Eukaryotic Sodium Channels -- 5 Modulation of Sodium Channels by Their C-Terminal Tail -- 6 Conclusion -- References -- The Cardiac Sodium Channel and Its Protein Partners -- 1 Introduction -- 2 Specialized Membrane Domains in Cardiac Sarcolemma -- 2.1 Intercalated Disk -- 2.2 Lateral Membrane -- 2.2.1 Costamere -- 2.2.2 T-Tubule System. |
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| Physical Description: | Online Resource |
| ISBN: | 9783319902845 |