Genome organization and function in the cell nucleus
By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety...
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| Other Authors: | |
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| Format: | Edited Volume |
| Language: | English |
| Published: |
Weinheim
John Wiley & Sons, Incorporated
2012
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| Edition: | 1st ed. |
| Volumes / Articles: | Show Volumes / Articles. |
| Subjects: | |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=843677
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| Author Notes: | ed. by Karsten Rippe |
| Summary: | By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come. Intro -- Genome Organization and Function in the Cell Nucleus -- Contents -- Preface -- List of Contributors -- 1: Deciphering DNA Sequence Information -- 1.1: Introduction -- 1.2: Genes and Transcribed Regions -- 1.2.1: Open Reading Frames -- 1.2.2: Mapping Transcriptional Start Sites -- 1.2.3: Mapping Untranslated Regions on mRNA -- 1.3: Non-Coding Genomic Elements -- 1.3.1: Pseudogenes -- 1.3.2: Repeats -- 1.3.3: Structural Variants -- 1.3.4: Methods for SV Detection -- 1.3.5: Transposons and Retrotransposons -- 1.4: Regulatory Information -- 1.4.1: Classes of Regulatory Elements -- 1.4.2: Transcription Factor Binding Motifs -- 1.4.3: Allele-Specific Expression -- 1.5: Individual Genetic Polymorphisms and Their Effect on Gene Expression -- 1.6: Conclusion -- 2: DNA Methylation -- 2.1: Introduction -- 2.1.1: Discovery of 5-Methylcytosine in DNA -- 2.1.2: Epigenetic Control of Gene Expression -- 2.2: Eukaryotic DNA Methyltransferases -- 2.2.1: Dnmt1 -- 2.2.2: The Dnmt3 Family -- 2.2.3: Cooperative Function of Dnmts -- 2.3: Distribution of 5-Methylcytosine in the Mammalian Genome -- 2.3.1: Spatial Distribution of 5-Methylcytosine -- 2.3.2: CpG Islands and Promoter Regulation -- 2.3.3: Repetitive DNA Sequences -- 2.3.4: Temporal Distribution of 5-Methylcytosine -- 2.4: Control of Gene Expression by DNA Methylation -- 2.4.1: Loss of Transcription Factor Binding -- 2.4.2: Methyl-CpG Binding Proteins -- 2.4.3: Interconnection of DNA Methylation with Other Epigenetic Pathways -- 2.4.4: DNA Methylation, Higher Order Chromatin Structure, and Nuclear Architecture -- 2.5: DNA Demethylation -- 3: Nucleosomes as Control Elements for Accessing the Genome -- 3.1: Introduction and Basic Terminology -- 3.2: Nucleosomes are the Building Blocks of Chromatin -- 3.2.1: Histones -- 3.2.2: Protein DNA Interactions in the Nucleosome. |
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| Item Description: | Description based on publisher supplied metadata and other sources |
| Physical Description: | Online Resource |
| ISBN: | 9783527640010 |