Genome organization and function in the cell nucleus
By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety...
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| Other Authors: | |
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| Format: | Edited Volume |
| Language: | English |
| Published: |
Weinheim
John Wiley & Sons, Incorporated
2012
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| Edition: | 1st ed. |
| Volumes / Articles: | Show Volumes / Articles. |
| Subjects: | |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=843677 Verlag, Volltext: http://gbv.eblib.com/patron/FullRecord.aspx?p=843677 
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| Author Notes: | ed. by Karsten Rippe |
Table of Contents:
- Cover; Contents; Title; Copyright; Dedication; Preface; List of Contributors; Chapter 1: Deciphering DNA Sequence Information; 1.1 Introduction; 1.2 Genes and Transcribed Regions; 1.3 Non-Coding Genomic Elements; 1.4 Regulatory Information; 1.5 Individual Genetic Polymorphisms and Their Effect on Gene Expression; 1.6 Conclusion; Acknowledgments; Chapter 2: DNA Methylation; 2.1 Introduction; 2.2 Eukaryotic DNA Methyltransferases; 2.3 Distribution of 5-Methylcytosine in the Mammalian Genome; 2.4 Control of Gene Expression by DNA Methylation; 2.5 DNA Demethylation
- Chapter 3: Nucleosomes as Control Elements for Accessing the Genome3.1 Introduction and Basic Terminology; 3.2 Nucleosomes are the Building Blocks of Chromatin; 3.3 Nucleosomes Are Dynamic Macromolecular Assemblies; 3.4 Histone Variants and Their Effect on Nucleosome Structure and Dynamics; 3.5 Histone Modifications in Nucleosome and Chromatin Structure; 3.6 DNA Sequence and Nucleosome Positioning; 3.7 Histone Chaperones and Chromatin Dynamics; 3.8 Outlook and Concluding Remarks; Chapter 4: Histone Modifications and Their Role as Epigenetic Marks; 4.1 The Complexity of Histone Modifications
- 4.2 Regulating Histone Modifications in Chromatin4.3 The "Histone Code" Hypothesis; 4.4 Exploiting the Complexity of the Histone Code: "Crosstalk" Between Different Modifications; 4.5 Are Histone Modifications Heritable Epigenetic Marks?; 4.6 Conclusions; Chapter 5: Chromatin Remodeling and Nucleosome Positioning; 5.1 Introduction; 5.2 Chromatin Remodeling Complexes; 5.3 Mechanisms of Nucleosome Translocations; 5.4 Positioning Nucleosomes in the Genome; 5.5 Gene Regulation via Nucleosome Positioning; 5.6 Conclusions; Acknowledgments; Chapter 6: The Folding of the Nucleosome Chain
- 6.1 Introduction6.2 Experimental Systems; 6.3 Nucleosome-Nucleosome Interactions; 6.4 DNA Interactions with the Histone Octamer Protein Core; 6.5 Architectural Chromosomal Proteins and Chromatin States; 6.6 Chromatin Fiber Conformations; 6.7 Conclusions; Acknowledgments; Chapter 7: The Crowded Environment of the Genome; 7.1 Introduction; 7.2 Basics; 7.3 Physicochemical Parameters of the Genome's Environment; 7.4 Implications of a Crowded Environment for the Conformation of the Interphase Genome; 7.5 Assembly and Localization of Macromolecular Machines for Genome Transcription and Replication
- 7.6 The Environment of the Genome during Mitosis7.7 Effects of a Crowded Environment on Searching for Targets in the Genome; 7.8 The Relative Importance of Entropic and Ionic Interactions for the Conformations and Interactions of Macromolecules in the Nucleus; 7.9 The Evolution of Genomes; Chapter 8: The Nuclear Lamina as a Chromatin Organizer; 8.1 Introduction; 8.2 Genome Organization with Respect to the Nuclear Periphery; 8.3 Interactions between NE Proteins and Chromatin Proteins/Chromatin Regulatory Proteins; 8.4 Mechanisms Directing Changes in Genome Organization during Development
- 8.5 Gene Regulation as a Consequence of Peripheral Positioning