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Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma: correlation with clinicopathological data and comparison of antibodies

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Cholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent advances, to date there is still no established targeted therapeutic approach available. Non-surgical therapeutic agents are urgently needed, as most patients are no...

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Main Authors: Kriegsmann, Mark (Author) , Rössler, Stephanie (Author) , Kriegsmann, Katharina (Author) , Renner, Marcus (Author) , Longuespée, Rémi (Author) , Albrecht, Thomas (Author) , Löffler, Moritz (Author) , Singer, Stephan (Author) , Mehrabi, Arianeb (Author) , Vogel, Monika Nadja (Author) , Pathil-Warth, Anita (Author) , Köhler, Bruno Christian (Author) , Springfeld, Christoph (Author) , Rupp, Christian (Author) , Weiss, Karl Heinz (Author) , Goeppert, Benjamin (Author)
Format: Article (Journal)
Language:English
Published: 15 January 2019
In: BMC cancer
Year: 2019, Volume: 19
ISSN:1471-2407
DOI:10.1186/s12885-018-5254-0
Online Access:Verlag, Volltext: https://doi.org/10.1186/s12885-018-5254-0
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Author Notes:Mark Kriegsmann, Stephanie Roessler, Katharina Kriegsmann, Marcus Renner, Rémi Longuespée, Thomas Albrecht, Moritz Loeffler, Stephan Singer, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss and Benjamin Goeppert
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Summary:Cholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent advances, to date there is still no established targeted therapeutic approach available. Non-surgical therapeutic agents are urgently needed, as most patients are non-eligible to surgical resection. Anti-PD-L1 therapy prevents cancer cells from evading the immune system and has emerged as a new treatment option in several cancer entities. Recently, PD-L1 expression has been analyzed in comparably small CCA patient cohorts. However, a systematic validation of different PD-L1 antibodies has not been performed in CCA so far.
Item Description:Gesehen am 10.05.2019
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-018-5254-0

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