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Identification of novel antigens contributing to autoimmunity in cardiovascular diseases

In myocarditis and dilated cardiomyopathy (DCM) patients the immune system may play an important role in disease progression. In this study, we aimed to identify new antigens as a target for autoimmune response that might play a crucial role in these diseases. Therefore, a peptide-array was used to...

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Main Authors: Müller, Anna-Maria (Author) , Bockstahler, Mariella (Author) , Hristov, Georgi (Author) , Weiß, Christel (Author) , Fischer, Andrea (Author) , Korkmaz-İçöz, Sevil (Author) , Giannitsis, Evangelos (Author) , Poller, Wolfgang (Author) , Katus, Hugo (Author) , Kaya, Ziya (Author)
Format: Article (Journal)
Language:English
Published: December 2016
In: Clinical immunology
Year: 2016, Volume: 173, Pages: 64-75
ISSN:1521-7035
DOI:10.1016/j.clim.2016.09.003
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.clim.2016.09.003
Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S1521661616303709
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Author Notes:Anna-Maria Müller, Mariella Bockstahler, Georgi Hristov, Christel Weiß, Andrea Fischer, Sevil Korkmaz-Icöz, Evangelos Giannitsis, Wolfgang Poller, Heinz-Peter Schultheiss, Hugo A. Katus, Ziya Kaya
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Summary:In myocarditis and dilated cardiomyopathy (DCM) patients the immune system may play an important role in disease progression. In this study, we aimed to identify new antigens as a target for autoimmune response that might play a crucial role in these diseases. Therefore, a peptide-array was used to investigate antibody binding profiles in patients with autoimmune myocarditis or DCM compared to healthy controls and thus to identify disease relevant antigens. To analyze the pathogenicity of the identified antigens, an experimental autoimmune myocarditis (EAM) model was used. Hereby, 3 peptide sequences, derived from myosin-binding-protein-C (MYBPC) fast-type, RNA-binding-protein 20 (RBM20), and dystrophin, showed pathogenic effects on the myocardium of mice. In summary, 3 potentially cardiopathogenic peptides (MYBPC fast-type, RBM20, dystrophin) were identified. Thus, this study could serve as a basis for future investigations aimed at determining further antigens leading to pathogenic effects on the myocardium of DCM as well as myocarditis patients.
Item Description:Gesehen am 28.03.2019
Available online 12 September 2016
Physical Description:Online Resource
ISSN:1521-7035
DOI:10.1016/j.clim.2016.09.003

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