Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia
Long non-coding RNAs (lncRNAs) have emerged as a novel class of RNA due to its diverse mechanism in cancer development and progression. However, the role and expression pattern of lncRNAs in molecular subtypes of B cell acute lymphoblastic leukemia (BCP-ALL) have not yet been investigated. Here, we...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 January 2019
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| In: |
Journal of hematology & oncology
Year: 2019, Jahrgang: 12, Pages: 1-16 |
| ISSN: | 1756-8722 |
| DOI: | 10.1186/s13045-018-0692-3 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1186/s13045-018-0692-3 Verlag, Volltext: https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-018-0692-3 
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| Verfasserangaben: | Alva Rani James, Michael P. Schroeder, Martin Neumann, Lorenz Bastian, Cornelia Eckert, Nicola Gökbuget, Jutta Ortiz Tanchez, Cornelia Schlee, Konstandina Isaakidis, Stefan Schwartz, Thomas Burmeister, Arend von Stackelberg, Michael A. Rieger, Stefanie Göllner, Martin Horstman, Martin Schrappe, Renate Kirschner-Schwabe, Monika Brüggemann, Carsten Müller-Tidow, Hubert Serve, Altuna Akalin and Claudia D. Baldus |
| Zusammenfassung: | Long non-coding RNAs (lncRNAs) have emerged as a novel class of RNA due to its diverse mechanism in cancer development and progression. However, the role and expression pattern of lncRNAs in molecular subtypes of B cell acute lymphoblastic leukemia (BCP-ALL) have not yet been investigated. Here, we assess to what extent lncRNA expression and DNA methylation is driving the progression of relapsed BCP-ALL subtypes and we determine if the expression and DNA methylation profile of lncRNAs correlates with established BCP-ALL subtypes. |
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| Beschreibung: | Gesehen am 29.03.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 1756-8722 |
| DOI: | 10.1186/s13045-018-0692-3 |