Cover Image

Molecular evolution of early-onset prostate cancer identifies molecular risk markers and clinical trajectories

Summary - Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characte...

Full description

Saved in:
Bibliographic Details
Main Authors: Gerhäuser, Clarissa (Author) , Feuerbach, Lars (Author) , Assenov, Yassen (Author) , Hübschmann, Daniel (Author) , Kuryshev, Vladimir (Author) , Weichenhan, Dieter (Author) , Toth, Reka (Author) , Lutsik, Pavlo (Author) , Lawerenz, Christian (Author) , Eils, Roland (Author) , Schlesner, Matthias (Author) , Kalle, Christof von (Author) , Sültmann, Holger (Author) , Brors, Benedikt (Author) , Plass, Christoph (Author) , Korbel, Jan Oliver (Author)
Format: Article (Journal)
Language:English
Published: 10 December 2018
In: Cancer cell
Year: 2018, Volume: 34, Issue: 6, Pages: 996-1011.e8
ISSN:1878-3686
DOI:10.1016/j.ccell.2018.10.016
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.ccell.2018.10.016
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1535610818304823
Get full text
Author Notes:Clarissa Gerhauser, Francesco Favero, Thomas Risch, Ronald Simon, Lars Feuerbach, Yassen Assenov, Doreen Heckmann, Nikos Sidiropoulos, Sebastian M. Waszak, Daniel Hübschmann, Alfonso Urbanucci, Etsehiwot G. Girma, Vladimir Kuryshev, Leszek J. Klimczak, Natalie Saini, Adrian M. Stütz, Dieter Weichenhan, Lisa-Marie Böttcher, Reka Toth, Josephine D. Hendriksen, Christina Koop, Pavlo Lutsik, Sören Matzk, Hans-Jörg Warnatz, Vyacheslav Amstislavskiy, Clarissa Feuerstein, Benjamin Raeder, Olga Bogatyrova, Eva-Maria Schmitz, Claudia Hube-Magg, Martina Kluth, Hartwig Huland, Markus Graefen, Chris Lawerenz, Gervaise H. Henry, Takafumi N. Yamaguchi, Alicia Malewska, Jan Meiners, Daniela Schilling, Eva Reisinger, Roland Eils, Matthias Schlesner, Douglas W. Strand, Robert G. Bristow, Paul C. Boutros, Christof von Kalle, Dmitry Gordenin, Holger Sültmann, Benedikt Brors, Guido Sauter, Christoph Plass, Marie-Laure Yaspo, Jan O. Korbel, Thorsten Schlomm, Joachim Weischenfeldt
Description
Summary:Summary - Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Our integrative analysis identified four molecular subgroups, including a particularly aggressive subgroup with recurrent duplications associated with increased expression of ESRP1, which we validate in 12,000 tissue microarray tumors. Finally, we combined the patterns of molecular co-occurrence and risk-based subgroup information to deconvolve the molecular and clinical trajectories of prostate cancer from single patient samples.
Item Description:Gesehen am 29.03.2019
Physical Description:Online Resource
ISSN:1878-3686
DOI:10.1016/j.ccell.2018.10.016

Similar Items