Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement
Background Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce. Objective To evaluate the overall association of HE-associated factors with clinical...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[September 2018]
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| In: |
Contact dermatitis
Year: 2018, Volume: 79, Issue: 3, Pages: 136-148 |
| ISSN: | 1600-0536 |
| DOI: | 10.1111/cod.13041 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1111/cod.13041 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/cod.13041 
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| Author Notes: | Simone Cazzaniga, Barbara K. Ballmer‐Weber, Nora Gräni, Philippe Spring, Andreas Bircher, Mark Anliker, Anne-Katharina Sonntag, Pierre Piletta, Caroline Huber, Thomas L. Diepgen, Christian Apfelbacher, Luigi Naldi, Luca Borradori, Dagmar Simon |
| Summary: | Background Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce. Objective To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years. Methods Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses. Results Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified. Conclusions Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE. |
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| Item Description: | First published: 25 June 2018 Gesehen am 02.04.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1600-0536 |
| DOI: | 10.1111/cod.13041 |