Lighting a fire in the tumor microenvironment using oncolytic immunotherapy
Oncolytic virus (OV) therapy is potentially a game-changing cancer treatment that has garnered significant interest due to its versatility and multi-modal approaches towards tumor eradication. In the field of cancer immunotherapy, the immunological phenotype of the tumor microenvironment (TME) is an...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 April 2018
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| In: |
EBioMedicine
Year: 2018, Volume: 31, Pages: 17-24 |
| ISSN: | 2352-3964 |
| DOI: | 10.1016/j.ebiom.2018.04.020 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.ebiom.2018.04.020 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2352396418301488 
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| Author Notes: | Carole Achard, Abera Surendran, Marie-Eve Wedge, Guy Ungerechts, John Bell, Carolina S. Ilkow |
| Summary: | Oncolytic virus (OV) therapy is potentially a game-changing cancer treatment that has garnered significant interest due to its versatility and multi-modal approaches towards tumor eradication. In the field of cancer immunotherapy, the immunological phenotype of the tumor microenvironment (TME) is an important determinant of disease prognosis and therapeutic success. There is accumulating data that OVs are capable of dramatically altering the TME immune landscape, leading to improved antitumor activity alone or in combination with assorted immune modulators. Herein, we review how OVs disrupt the immunosuppressive TME and can be used strategically to create a “pro-immune” microenvironment that enables and promotes potent, long-lasting host antitumor immune responses. |
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| Item Description: | Gesehen am 04.04.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2352-3964 |
| DOI: | 10.1016/j.ebiom.2018.04.020 |