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MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo

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Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular networks in vivo, however, remain poorly investigated. Arteriovenous (AV) shunts are an established model for induction of neoangiogene...

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Main Authors: Henn, Dominic (Author) , Falkner, Florian (Author) , Thomas, Benjamin (Author) , Köpple, Christoph (Author) , Schulte, Matthias (Author) , Kneser, Ulrich (Author) , Schmidt, Volker-Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 11 January 2019
In: Journal of translational medicine
Year: 2019, Volume: 17, Pages: 1-19
ISSN:1479-5876
DOI:10.1186/s12967-019-1767-9
Online Access:Verlag, Volltext: https://doi.org/10.1186/s12967-019-1767-9
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Author Notes:Dominic Henn, Masood Abu-Halima, Dominik Wermke, Florian Falkner, Benjamin Thomas, Christoph Köpple, Nicole Ludwig, Matthias Schulte, Marc A. Brockmann, Yoo-Jin Kim, Justin M. Sacks, Ulrich Kneser, Andreas Keller, Eckart Meese and Volker J. Schmidt
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Summary:Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular networks in vivo, however, remain poorly investigated. Arteriovenous (AV) shunts are an established model for induction of neoangiogenesis in vivo and can serve as a tool for analysis of hemodynamic effects on miRNA and gene expression profiles over time.
Item Description:Gesehen am 04.04.2019
Physical Description:Online Resource
ISSN:1479-5876
DOI:10.1186/s12967-019-1767-9

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