Differential use of the C-type lectins L-SIGN and DC-SIGN for phlebovirus endocytosis
The receptors and cellular factors used by phleboviruses (Bunyaviridae) to enter host cells remain largely unidentified. In addition to the C-type lectin DC-SIGN (Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin), we report here that several phleboviruses subvert the c...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016 Apr 21
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| In: |
Traffic
Year: 2016, Volume: 17, Issue: 6, Pages: 639-656 |
| ISSN: | 1600-0854 |
| DOI: | 10.1111/tra.12393 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1111/tra.12393 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tra.12393 
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| Author Notes: | Psylvia Léger, Marilou Tetard, Berthe Youness, Nicole Cordes, Ronan N. Rouxel, Marie Flamand and Pierre-Yves Lozach |
| Summary: | The receptors and cellular factors used by phleboviruses (Bunyaviridae) to enter host cells remain largely unidentified. In addition to the C-type lectin DC-SIGN (Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin), we report here that several phleboviruses subvert the closely related protein L-SIGN for infection. Together, our results establish that L-SIGN is an attachment factor not required for virus internalization whereas DC-SIGN is an authentic entry receptor required for both binding and endocytosis. Our study underlines the importance of the subsequent entry processes in virus-receptor interactions beyond attachment. |
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| Item Description: | Gesehen am 10.04.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1600-0854 |
| DOI: | 10.1111/tra.12393 |