Male increase in brain gene expression variability is linked to genetic risk for schizophrenia
Schizophrenia shows substantial sex differences in age of onset, course, and treatment response, but the biological basis of these effects is incompletely understood. Here we show that during human development, males show a regionally specific decrease in brain expression similarity compared to fema...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 August 2018
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| In: |
Translational Psychiatry
Year: 2018, Volume: 8, Pages: 1-10 |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-018-0200-0 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41398-018-0200-0 Verlag, Volltext: https://www.nature.com/articles/s41398-018-0200-0 
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| Author Notes: | Junfang Chen, Han Cao, Andreas Meyer-Lindenberg, Emanuel Schwarz |
| Summary: | Schizophrenia shows substantial sex differences in age of onset, course, and treatment response, but the biological basis of these effects is incompletely understood. Here we show that during human development, males show a regionally specific decrease in brain expression similarity compared to females. The genes modulating this effect were significantly co-expressed with schizophrenia risk genes during prefrontal cortex brain development in the fetal period as well as during early adolescence. This suggests a genetic contribution to a mechanism through which developmental abnormalities manifest with psychosis during adolescence. It further supports sex differences in brain expression variability as a factor underlying the well-established sex differences in schizophrenia. |
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| Item Description: | Gesehen am 12.04.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-018-0200-0 |