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Diastereoselective synthesis of peptidomimetics in one-pot Ugi reaction using trans-4-isopropylcyclohexanecarboxylic acid

The use of trans-4-isopropylcyclohexanecarboxylic acid as a substitution for the carboxylic acid component in the Ugi multicomponent condensation that leads to (1R,4R)-N-(2-(cyclohexylamino)-2-oxo-4-isopropylcyclohexane-1-carboxamide derivatives is described for the first time. One pot, clean reacti...

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Bibliographic Details
Main Authors: Ramezanpour, Sorour (Author) , Panahi, Akram (Author) , Rominger, Frank (Author)
Format: Article (Journal)
Language:English
Published: 01 February 2018
In: Monatshefte für Chemie
Year: 2018, Volume: 149, Issue: 3, Pages: 625-633
ISSN:1434-4475
DOI:10.1007/s00706-017-2086-6
Online Access:Verlag, Volltext: https://doi.org/10.1007/s00706-017-2086-6
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Author Notes:Sorour Ramezanpour, Akram Panahi, Frank Rominger
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Summary:The use of trans-4-isopropylcyclohexanecarboxylic acid as a substitution for the carboxylic acid component in the Ugi multicomponent condensation that leads to (1R,4R)-N-(2-(cyclohexylamino)-2-oxo-4-isopropylcyclohexane-1-carboxamide derivatives is described for the first time. One pot, clean reaction, and excellent yields are some advantages of this protocol.Graphical abstract Open image in new window
Item Description:Gesehen am 15.04.2019
Physical Description:Online Resource
ISSN:1434-4475
DOI:10.1007/s00706-017-2086-6

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