Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain

Summary - The function of somatic stem cells declines with age. Understanding the molecular underpinnings of this decline is key to counteract age-related disease. Here, we report a dramatic drop in the neural stem cells (NSCs) number in the aging murine brain. We find that this smaller stem cell re...

Full description

Bibliographic Details

Main Authors:	Kalamakis, Georgios (Author) , Stiehl, Thomas (Author) , Kupke, Janina (Author) , Mallm, Jan-Philipp (Author) , Anders, Simon (Author) , Marciniak-Czochra, Anna (Author) , Martín-Villalba, Ana (Author)
Format:	Article (Journal)
Language:	English
Published:	March 7, 2019
In:	Cell Year: 2019, Volume: 176, Issue: 6, Pages: 1407-1419.e14
ISSN:	1097-4172
DOI:	10.1016/j.cell.2019.01.040
Online Access:	Verlag, Volltext: https://doi.org/10.1016/j.cell.2019.01.040 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0092867419301035
Author Notes:	Georgios Kalamakis, Daniel Brüne, Srikanth Ravichandran, Jan Bolz, Wenqiang Fan, Frederik Ziebell, Thomas Stiehl, Francisco Catalá-Martinez, Janina Kupke, Sheng Zhao, Enric Llorens-Bobadilla, Katharina Bauer, Stefanie Limpert, Birgit Berger, Urs Christen, Peter Schmezer, Jan Philipp Mallm, Benedikt Berninger, Simon Anders, Antonio del Sol, Anna Marciniak-Czochra, and Ana Martin-Villalba