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No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DN...

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Bibliographic Details
Main Authors: Bey, Katharina (Author) , Frölich, Lutz (Author)
Format: Article (Journal)
Language:English
Published: 19 April 2016
In: Epigenomics
Year: 2016, Volume: 8, Issue: 5, Pages: 593-598
ISSN:1750-192X
DOI:10.2217/epi-2015-0014
Online Access:Verlag, Volltext: https://doi.org/10.2217/epi-2015-0014
Verlag, Volltext: https://www.futuremedicine.com/doi/10.2217/epi-2015-0014
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Author Notes:Katharina Bey, Steffen Wolfsgruber, Ilker Karaca, Holger Wagner, Roy Lardenoije, Julian Becker, Esther Milz, Johannes Kornhuber, Oliver Peters, Lutz Frölich, Michael Hüll, Eckart Rüther, Jens Wiltfang, Steffi Riedel-Heller, Martin Scherer, Frank Jessen, Wolfgang Maier, Daniel L. van den Hove, Bart P.F. Rutten, Michael Wagner and Alfredo Ramirez
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Summary:Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.
Item Description:Gesehen am 29.04.2019
Physical Description:Online Resource
ISSN:1750-192X
DOI:10.2217/epi-2015-0014

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