No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment
Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DN...
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| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 April 2016
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| In: |
Epigenomics
Year: 2016, Volume: 8, Issue: 5, Pages: 593-598 |
| ISSN: | 1750-192X |
| DOI: | 10.2217/epi-2015-0014 |
| Online Access: | Verlag, Volltext: https://doi.org/10.2217/epi-2015-0014 Verlag, Volltext: https://www.futuremedicine.com/doi/10.2217/epi-2015-0014 
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| Author Notes: | Katharina Bey, Steffen Wolfsgruber, Ilker Karaca, Holger Wagner, Roy Lardenoije, Julian Becker, Esther Milz, Johannes Kornhuber, Oliver Peters, Lutz Frölich, Michael Hüll, Eckart Rüther, Jens Wiltfang, Steffi Riedel-Heller, Martin Scherer, Frank Jessen, Wolfgang Maier, Daniel L. van den Hove, Bart P.F. Rutten, Michael Wagner and Alfredo Ramirez |
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| 520 | |a Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI. | ||
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