Magnesium as an intrinsic component of human otoconia
OBJECTIVES: To investigate morphology changes of artificial otoconia (CGC) in the presence of magnesium during growth under in vitro conditions. - METHODS: Investigating human otoconia by environmental scanning electron microscope and determining their magnesium content by energy-dispersive X-ray mi...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 May 2018
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Acta oto-laryngologica
Year: 2018, Jahrgang: 138, Heft: 9, Pages: 775-778 |
| ISSN: | 1651-2251 |
| DOI: | 10.1080/00016489.2018.1467572 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1080/00016489.2018.1467572
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| Verfasserangaben: | Leif Erik Walther, Jana Wulfes, Alexander Blödow, Rüdiger Kniep |
| Zusammenfassung: | OBJECTIVES: To investigate morphology changes of artificial otoconia (CGC) in the presence of magnesium during growth under in vitro conditions. - METHODS: Investigating human otoconia by environmental scanning electron microscope and determining their magnesium content by energy-dispersive X-ray microanalysis (EDX). Comparing structural and morphological data of human and artificial otoconia (CGC, Ca1Mg0) without and with magnesium substitution (Ca1-xMgx). - RESULTS: EDX- and X-ray data reveals that the inorganic component in human otoconia consists of calcite containing a minor amount of magnesium substitution (Ca1-xMgx). CGC containing magnesium (length 397.0 ± 146.4 µm, diameter 325.6 ± 100.1 µm) are slimmer and significantly smaller (p < .01) than pure CGC (length 548.6 ± 160 µm, diameter 373.0 ± 110.4 µm) and reveal a significant influence on the final morphology. The length/diameter ratio is significantly higher by incorporation of magnesium into CGC (1.84 ± 0.25 µm versus 1.48 ± 0.11 µm in pure CGC, p < .01), which brings the overall shape to a close relationship with human otoconia (1.98 ± 0.08 µm). - CONCLUSIONS: Magnesium is an intrinsic component of human otoconia by partial substitution of calcium in the calcite crystal structure (Ca1-xMgx) and affects the development of the shape of artificial otoconia (calcite gelatin composites, CGC). |
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| Beschreibung: | Gesehen am 29.04.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 1651-2251 |
| DOI: | 10.1080/00016489.2018.1467572 |