Dose-response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect?
Purpose - To derive the dose-response curve for temporal lobe reactions (TLRs) after proton therapy and to compare the resulting relative biological effectiveness (RBE)-weighted tolerance doses based on an RBE of 1.1 with published values for carbon ions, which were calculated by the two versions of...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 February 2018
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| In: |
Radiotherapy and oncology
Year: 2018, Volume: 128, Issue: 1, Pages: 109-114 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2018.01.018 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.radonc.2018.01.018 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0167814018300446 
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| Author Notes: | Clarissa Gillmann, Antony J. Lomax, Damien C. Weber, Oliver Jäkel, Christian P. Karger |
| Summary: | Purpose - To derive the dose-response curve for temporal lobe reactions (TLRs) after proton therapy and to compare the resulting relative biological effectiveness (RBE)-weighted tolerance doses based on an RBE of 1.1 with published values for carbon ions, which were calculated by the two versions of the local effect model (LEM I or IV). - Methods and materials - 62 patients treated with protons for skull base tumors were analyzed for TLRs using magnetic resonance imaging. Within the mean follow-up time of 38months, TLRs were observed in six patients. Dose-response curves based on the RBE-weighted maximum dose, excluding the 1cm3-volume with the highest dose, were derived and compared to previously published dose-response curves for carbon ions, which were obtained using LEM I or IV, respectively. - Results - The dose-response curves for protons and LEM I were found to be almost identical while the curve of LEM IV was shifted toward higher doses. The resulting tolerance doses at the 5% effect level were 68.2+2.7-5.6, 68.6+3.0-3.9 and 78.3+3.8-5.0 Gy (RBE), respectively. - Conclusions - The RBE-weighted dose prescription for protons leads to the same RBE-weighted dose-response curve for TLR as the one for LEM I-based carbon ions, while LEM IV predicts clinically significant higher tolerance doses. |
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| Item Description: | Gesehen am 30.04.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2018.01.018 |