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Impact of age at diagnosis on disease progression in patients with primary sclerosing cholangitis

BackgroundThe median age of diagnosis of primary sclerosing cholangitis (PSC) is ?30?40 years.ObjectiveWe aimed to analyse disease progression and liver-dependent survival in patients diagnosed with PSC after 50 years of age.MethodsPatients with PSC were analysed with regard to their age at diagnosi...

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Main Authors: Rupp, Christian (Author) , Rößler, Alexander Fritz (Author) , Rauber, Conrad (Author) , Friedrich, Kilian (Author) , Wannhoff, Andreas (Author) , Weiss, Karl Heinz (Author) , Sauer, Peter (Author) , Schirmacher, Peter (Author) , Süsal, Caner (Author) , Stremmel, Wolfgang (Author) , Gotthardt, Daniel (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: United european gastroenterology journal
Year: 2018, Volume: 6, Issue: 2, Pages: 255-262
ISSN:2050-6414
DOI:10.1177/2050640617717156
Online Access:Verlag, Volltext: https://doi.org/10.1177/2050640617717156
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Author Notes:Christian Rupp, Alexander Rössler, Taotao Zhou, Conrad Rauber, Kilian Friedrich, Andreas Wannhoff, Karl-Heinz Weiss, Peter Sauer, Peter Schirmacher, Caner Süsal, Wolfgang Stremmel and Daniel N Gotthardt
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Summary:BackgroundThe median age of diagnosis of primary sclerosing cholangitis (PSC) is ?30?40 years.ObjectiveWe aimed to analyse disease progression and liver-dependent survival in patients diagnosed with PSC after 50 years of age.MethodsPatients with PSC were analysed with regard to their age at diagnosis. Patients with a first diagnosis of PSC after the age of 50 years were considered as the late-onset group.ResultsA total of 32/215 (14.9%) patients were diagnosed with PSC after 50 years of age. The proportion of females was significantly higher among patients with late-onset PSC (48.4 vs. 27.3%; p?=?0.02). Patients with later diagnosis required dilatation therapy more often due to dominant stenosis (84.2 vs. 53.1%; p?=?0.01) and suffered from recurrent cholangitis more often (48.3 vs. 21.0%; p?=?0.003). Patients with late-onset PSC had reduced transplantation-free survival (10.5?±?0.6 years vs. 20.8?±?1.7 years, p?
Item Description:First Published June 17, 2017
Gesehen am 03.05.2019
Physical Description:Online Resource
ISSN:2050-6414
DOI:10.1177/2050640617717156

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