Temporally resolved parametric assessment of Z-magnetization recovery (TOPAZ): dynamic myocardial T1 mapping using a cine steady-state look-locker approach
Purpose To develop and evaluate a cardiac phase-resolved myocardial T1 mapping sequence. Methods The proposed method for temporally resolved parametric assessment of Z-magnetization recovery (TOPAZ) is based on contiguous fast low-angle shot imaging readout after magnetization inversion from the pul...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Magnetic resonance in medicine
Year: 2017, Volume: 79, Issue: 4, Pages: 2087-2100 |
| ISSN: | 1522-2594 |
| DOI: | 10.1002/mrm.26887 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1002/mrm.26887
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| Author Notes: | Sebastian Weingärtner, Chetan Shenoy, Benedikt Rieger, Lothar R. Schad, Jeanette Schulz‐Menger, Mehmet Akçakaya |
| Summary: | Purpose To develop and evaluate a cardiac phase-resolved myocardial T1 mapping sequence. Methods The proposed method for temporally resolved parametric assessment of Z-magnetization recovery (TOPAZ) is based on contiguous fast low-angle shot imaging readout after magnetization inversion from the pulsed steady state. Thereby, segmented k-space data are acquired over multiple heartbeats, before reaching steady state. This results in sampling of the inversion-recovery curve for each heart phase at multiple points separated by an R-R interval. Joint T1 and estimation is performed for reconstruction of cardiac phase-resolved T1 and maps. Sequence parameters are optimized using numerical simulations. Phantom and in vivo imaging are performed to compare the proposed sequence to a spin-echo reference and saturation pulse prepared heart rate-independent inversion-recovery (SAPPHIRE) T1 mapping sequence in terms of accuracy and precision. Results In phantom, TOPAZ T1 values with integrated correction are in good agreement with spin-echo T1 values (normalized root mean square error = 4.2%) and consistent across the cardiac cycle (coefficient of variation = 1.4 ± 0.78%) and different heart rates (coefficient of variation = 1.2 ± 1.9%). In vivo imaging shows no significant difference in TOPAZ T1 times between the cardiac phases (analysis of variance: P = 0.14, coefficient of variation = 3.2 ± 0.8%), but underestimation compared with SAPPHIRE (T1 time ± precision: 1431 ± 56 ms versus 1569 ± 65 ms). In vivo precision is comparable to SAPPHIRE T1 mapping until middiastole (P > 0.07), but deteriorates in the later phases. Conclusions The proposed sequence allows cardiac phase-resolved T1 mapping with integrated assessment at a temporal resolution of 40 ms. Magn Reson Med 79:2087-2100, 2018. © 2017 International Society for Magnetic Resonance in Medicine. |
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| Item Description: | Published online 30 August 2017 Gesehen am 06.05.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1522-2594 |
| DOI: | 10.1002/mrm.26887 |