Fabry's disease: an important risk factor for stroke
In today's Lancet, Arndt Rolfs and colleagues describe the prevalence of Fabry's disease - (MIM 301500, α-galactosidase A mutations) in a large cohort of patients with cryptogenic - stroke.1 Fabry's disease is an under-recognised single-gene defect caused by α-galactosidase - A defici...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 09, 2005
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| In: |
The lancet
Year: 2005, Jahrgang: 366, Heft: 9499, Pages: 1754-1756 |
| ISSN: | 1474-547X |
| DOI: | 10.1016/S0140-6736(05)67636-2 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/S0140-6736(05)67636-2 Verlag, Volltext: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67636-2/abstract 
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| Verfasserangaben: | Raphael Schiffmann, Markus Ries |
| Zusammenfassung: | In today's Lancet, Arndt Rolfs and colleagues describe the prevalence of Fabry's disease - (MIM 301500, α-galactosidase A mutations) in a large cohort of patients with cryptogenic - stroke.1 Fabry's disease is an under-recognised single-gene defect caused by α-galactosidase - A deficiency, which results in a failure to catabolise α-D-galactosyl glycolipid moieties. - Increased concentrations of glycolipid are a risk factor for cardiomyopathy, cardiac - conduction abnormalities, valvular defects, coronary artery disease, renal failure, - and stroke. |
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| Beschreibung: | Gesehen am 08.05.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 1474-547X |
| DOI: | 10.1016/S0140-6736(05)67636-2 |