Circular RNAs in the cardiovascular system
Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding RNAs. Recent investigations showed that circRNAs are regulated in the cardiovascular system an...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 February 2018
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| In: |
Non-coding RNA research
Year: 2018, Jahrgang: 3, Heft: 1, Pages: 1-11 |
| ISSN: | 2468-0540 |
| DOI: | 10.1016/j.ncrna.2018.02.002 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.ncrna.2018.02.002 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2468054017300471 
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| Verfasserangaben: | Clarissa P.C. Gomes, Antonio Salgado-Somoza, Esther E. Creemers, Christoph Dieterich, Mitja Lustrek, Yvan Devaux on behalf of the Cardiolinc network2 |
| Zusammenfassung: | Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding RNAs. Recent investigations showed that circRNAs are regulated in the cardiovascular system and participate in its physiological and pathological development. In this review article, we will provide an overview of the role of circRNAs in cardiovascular health and disease. After a description of the biogenesis of circRNAs, we will summarize what is known of the expression, regulation and function of circRNAs in the cardiovascular system. We will then address some technical aspects of circRNAs research, discussing how artificial intelligence may aid in circRNAs research. Finally, the potential of circRNAs as biomarkers of cardiovascular disease will be addressed and directions for future research will be proposed. |
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| Beschreibung: | Gesehen am 10.05.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 2468-0540 |
| DOI: | 10.1016/j.ncrna.2018.02.002 |