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Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by most cancer cells via reversible state transitions i...

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Bibliographische Detailangaben
Hauptverfasser: Dirkse, Anne (VerfasserIn) , Herold-Mende, Christel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 April 2019
In: Nature Communications
Year: 2019, Jahrgang: 10, Pages: 1-16
ISSN:2041-1723
DOI:10.1038/s41467-019-09853-z
Online-Zugang:Verlag, Volltext: https://doi.org/10.1038/s41467-019-09853-z
Verlag, Volltext: https://www.nature.com/articles/s41467-019-09853-z
Volltext
Verfasserangaben:Anne Dirkse, Anna Golebiewska, Thomas Buder, Petr V. Nazarov, Arnaud Muller, Suresh Poovathingal, Nicolaas H.C. Brons, Sonia Leite, Nicolas Sauvageot, Dzjemma Sarkisjan, Mathieu Seyfrid, Sabrina Fritah, Daniel Stieber, Alessandro Michelucci, Frank Hertel, Christel Herold-Mende, Francisco Azuaje, Alexander Skupin, Rolf Bjerkvig, Andreas Deutsch, Anja Voss-Böhme, Simone P. Niclou
Beschreibung
Zusammenfassung:Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by most cancer cells via reversible state transitions induced by the microenvironment.
Beschreibung:Gesehen am 14.05.2019
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-09853-z

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