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Structural brain correlates of adolescent resilience

Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated wi...

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Main Authors: Burt, Keith (Author) , Banaschewski, Tobias (Author) , Flor, Herta (Author) , Mann, Karl (Author) , Poustka, Luise (Author) , Rietschel, Marcella (Author)
Format: Article (Journal)
Language:English
Published: 15 April 2016
In: The journal of child psychology and psychiatry
Year: 2016, Volume: 57, Issue: 11, Pages: 1287-1296
ISSN:1469-7610
DOI:10.1111/jcpp.12552
Online Access:Verlag, Volltext: https://doi.org/10.1111/jcpp.12552
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpp.12552
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Author Notes:Keith B. Burt, Robert Whelan, Patricia J. Conrod, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Mira Fauth‐Bühler, Herta Flor, André Galinowski, Juergen Gallinat, Penny Gowland, Andreas Heinz, Bernd Ittermann, Karl Mann, Frauke Nees, Dimitri Papadopoulos‐Orfanos, Tomas Paus, Zdenka Pausova, Luise Poustka, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Andreas Ströhle, Gunter Schumann, Hugh Garavan, and the IMAGEN Consortium
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Summary:Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity.
Item Description:Gesehen am 16.05.2019
Physical Description:Online Resource
ISSN:1469-7610
DOI:10.1111/jcpp.12552

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