Coronary CT angiography derived morphological and functional quantitative plaque markers correlated with invasive fractional flow reserve for detecting hemodynamically significant stenosis
Objective - Compare morphological and functional coronary plaque markers derived from coronary CT angiography (CCTA) for their ability to detect lesion-specific ischemia. - Materials and methods - Data of patients who had undergone both dual-source CCTA and invasive fractional flow reserve (FFR) mea...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 March 2016
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| In: |
Journal of cardiovascular computed tomography
Year: 2016, Volume: 10, Issue: 3, Pages: 199-206 |
| ISSN: | 1876-861X |
| DOI: | 10.1016/j.jcct.2016.03.002 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.jcct.2016.03.002 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1934592516300193 
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| Author Notes: | Christian Tesche, Carlo N. De Cecco, Damiano Caruso, Stefan Baumann, Matthias Renker, Stefanie Mangold, Kevin T. Dyer, Akos Varga-Szemes, Moritz Baquet, David Jochheim, Ullrich Ebersberger, Richard R. Bayer, Ellen Hoffmann, Daniel H. Steinberg, U. Joseph Schoepf |
| Summary: | Objective - Compare morphological and functional coronary plaque markers derived from coronary CT angiography (CCTA) for their ability to detect lesion-specific ischemia. - Materials and methods - Data of patients who had undergone both dual-source CCTA and invasive fractional flow reserve (FFR) measurement within 3 months were retrospectively analyzed. Various quantitative stenosis markers were derived from CCTA: Corrected coronary opacification (CCO), transluminal attenuation gradient (TAG), remodeling index (RI), computational FFR (cFFR), lesion length (LL), vessel volume (VV), total plaque volume (TPV), and calcified and non-calcified plaque volume (CPV and NCPV). Discriminatory power of these markers for flow-limiting versus non-significant coronary stenosis was assessed against invasive FFR as the reference standard. - Results - The cohort included 37 patients (61 ± 12 years, 68% male). Among 37 lesions, 11 were hemodynamically significant by FFR. On a per-lesion level, sensitivity and specificity of TPV, CPV, and NCPV for hemodynamically significant stenosis detection were 88% and 74%, 67% and 53%, and 92% and 81%, respectively. For CCO, TAG, RI, and cFFR these were 64% and 86%, 35% and 56%, 82% and 54%, and 100% and 90%, respectively. At ROC analysis, only TPV (0.78, p = 0.013), NCPV (0.79, p = 0.009), cFFR (0.85, p = 0.003), and CCO (0.82, p = 0.0003) showed discriminatory power for detecting hemodynamically significant stenosis. - Conclusion - TPV, NCPV, CCO, and cFFR derived from CCTA can aid detecting hemodynamically significant coronary lesions with cFFR showing the greatest discriminatory ability. |
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| Item Description: | Gesehen am 22.05.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1876-861X |
| DOI: | 10.1016/j.jcct.2016.03.002 |