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Body fatness, adipose tissue compartments, and biomarkers of inflammation and angiogenesis in colorectal cancer: the ColoCare Study

Background: Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients...

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Main Authors: Himbert, Caroline (Author) , Ose, Jennifer (Author) , Nattenmüller, Johanna (Author) , Warby, Christy A. (Author) , Holowatyi, Andreana N. (Author) , Böhm, Jürgen (Author) , Lin, Tengda (Author) , Haffa, Mariam (Author) , Gigić, Biljana (Author) , Hardikar, Sheetal (Author) , Scherer, Dominique (Author) , Zielske, Lin (Author) , Schrotz-King, Petra (Author) , Kölsch, Torsten (Author) , Siegel, Erin M. (Author) , Shibata, David (Author) , Ulrich, Alexis (Author) , Schneider, Martin (Author) , Hursting, Stephen D. (Author) , Kauczor, Hans-Ulrich (Author) , Ulrich, Cornelia (Author)
Format: Article (Journal)
Language:English
Published: January 2019
In: Cancer epidemiology, biomarkers & prevention
Year: 2019, Volume: 28, Issue: 1, Pages: 76-82
ISSN:1538-7755
DOI:10.1158/1055-9965.EPI-18-0654
Online Access:Verlag, Volltext: https://doi.org/10.1158/1055-9965.EPI-18-0654
Verlag, Volltext: http://cebp.aacrjournals.org/content/28/1/76
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Author Notes:Caroline Himbert, Jennifer Ose, Johanna Nattenmüller, Christy A. Warby, Andreana N. Holowatyj, Jürgen Böhm, Tengda Lin, Mariam Haffa, Biljana Gigic, Sheetal Hardikar, Dominique Scherer, Lin Zielske, Petra Schrotz-King, Torsten Kölsch, Erin M. Siegel, David Shibata, Alexis Ulrich, Martin Schneider, Stephen D. Hursting, Hans-Ulrich Kauczor, and Cornelia M. Ulrich
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Summary:Background: Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients with colorectal cancer. - Methods: Preoperative serum samples and computed tomography scans were obtained from 188 patients diagnosed with primary invasive stage I-IV colorectal cancer enrolled in the ColoCare Study. Adiposity was assessed by area-based quantification of VFA, SFA, and VFA:SFA ratio on spinal levels L3/L4 and L4/L5. Circulating levels of inflammation (CRP, SAA, sICAM-1, and sVCAM-1) and angiogenesis (VEGF-A and VEGF-D) were assessed from patient sera on the Meso Scale Discovery platform. Partial correlations and regression analyses, adjusted for age, sex, and tumor stage, were performed. - Results: VFA was moderately correlated with CRP and SAA (CRP: L3/L4 and L4/L5:r = 0.21, P = 0.01; SAA: L3/L4:r = 0.17, P = 0.04). The correlation between SFA and the measured biomarkers were weak (r ≤ 0.13, not significant). The ratio of VFA:SFA at L3/L4 was moderately correlated with VEGF-A (r = 0.28, P = 0.0008) and SAA (r = 0.24, P = 0.006), and less so with CRP (r = 0.18, P = 0.04) and sICAM-1 (r = 0.18, P = 0.04). Similar correlations were found for the VFA:SFA ratio at L4/L5. - Conclusions: We observed an association between visceral adiposity and biomarkers of inflammation and angiogenesis in colorectal cancer. In particular, the VFA:SFA ratio was correlated with circulating levels of the proangiogenic biomarker VEGF-A. - Impact: Our findings support a direct association of visceral adipose tissue with inflammatory and angiogenic processes, which play fundamental roles in the development and progression of colorectal cancer.
Item Description:Gesehen am 24.05.2019
Physical Description:Online Resource
ISSN:1538-7755
DOI:10.1158/1055-9965.EPI-18-0654

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