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Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients

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CD4+ T cells are of great importance in the pathogenesis of systemic lupus erythematosus (SLE), as an imbalance between CD4+ regulatory T cells (Tregs) and CD4+ responder T cells (Tresps) causes flares of active disease in SLE patients. In this study, we aimed to find the role of aberrant Treg/Tresp...

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Main Authors: Schaier, Matthias (Author) , Gottschalk, Claudius (Author) , Uhlmann, Lorenz (Author) , Speer, Claudius (Author) , Kälble, Florian (Author) , Eckstein, Volker (Author) , Müller-Tidow, Carsten (Author) , Meuer, Stefan (Author) , Mahnke, Karsten (Author) , Lorenz, Hanns-Martin (Author) , Zeier, Martin (Author) , Steinborn-Kröhl, Andrea (Author)
Format: Article (Journal)
Language:English
Published: 18 December 2018
In: Arthritis Research & Therapy
Year: 2018, Volume: 20, Pages: 1-17
ISSN:1465-9913
DOI:10.1186/s13075-018-1778-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13075-018-1778-6
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Author Notes:Matthias Schaier, Claudius Gottschalk, Lorenz Uhlmann, Claudius Speer, Florian Kälble, Volker Eckstein, Carsten Müller-Tidow, Stefan Meuer, Karsten Mahnke, Hanns-Martin Lorenz, Martin Zeier and Andrea Steinborn
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Summary:CD4+ T cells are of great importance in the pathogenesis of systemic lupus erythematosus (SLE), as an imbalance between CD4+ regulatory T cells (Tregs) and CD4+ responder T cells (Tresps) causes flares of active disease in SLE patients. In this study, we aimed to find the role of aberrant Treg/Tresp cell differentiation for maintaining Treg/Tresp cell balance and Treg functionality.
Item Description:Gesehen am 26.11.2024
Physical Description:Online Resource
ISSN:1465-9913
DOI:10.1186/s13075-018-1778-6

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