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Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that un...

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Bibliographic Details
Main Authors: López, Cristina (Author) , Kleinheinz, Kortine (Author) , Hübschmann, Daniel (Author) , Raimondi, Francesco (Author) , Russell, Robert B. (Author) , Eils, Roland (Author)
Format: Article (Journal)
Language:English
Published: 29 March 2019
In: Nature Communications
Year: 2019, Volume: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-08578-3
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-019-08578-3
Verlag, Volltext: https://www.nature.com/articles/s41467-019-08578-3
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Author Notes:Cristina López, Kortine Kleinheinz, Sietse M. Aukema, Marius Rohde, Stephan H. Bernhart, Daniel Hübschmann, Rabea Wagener, Umut H. Toprak, Francesco Raimondi, Markus Kreuz, Sebastian M. Waszak, Zhiqin Huang, Lina Sieverling, Nagarajan Paramasivam, Julian Seufert, Stephanie Sungalee, Robert B. Russell, Julia Bausinger, Helene Kretzmer, Ole Ammerpohl, Anke K. Bergmann, Hans Binder, Arndt Borkhardt, Benedikt Brors, Alexander Claviez, Gero Doose, Lars Feuerbach, Andrea Haake, Martin-Leo Hansmann, Jessica Hoell, Michael Hummel, Jan O. Korbel, Chris Lawerenz, Dido Lenze, Bernhard Radlwimmer, Julia Richter, Philip Rosenstiel, Andreas Rosenwald, Markus B. Schilhabel, Harald Stein, Stephan Stilgenbauer, Peter F. Stadler, Monika Szczepanowski, Marc A. Weniger, Marc Zapatka, Roland Eils, Peter Lichter, Markus Loeffler, Peter Möller, Lorenz Trümper, Wolfram Klapper (ICGC MMML-Seq Consortium), Steve Hoffmann, Ralf Küppers, Birgit Burkhardt, Matthias Schlesner & Reiner Siebert ; ICGC MMML-Seq Consortium: Susanne Wagner, Gesine Richter, Jürgen Eils3 Jules Kerssemakers, Christina Jaeger-Schmidt, Ingrid Scholz, Christoph Borst, Friederike Braulke, Martin Dreyling, Sonja Eberth, Hermann Einsele, Norbert Frickhofen, Siegfried Haas, Dennis Karsch, Nicole Klepl, Michael Kneba, Jasmin Lisfeld, Luisa Mantovani-Löffler, German Ott, Christina Stadler, Peter Staib, Thorsten Zenz, Dieter Kube, Ulrike Kostezka, Vera Binder, Ellen Leich, Inga Nagel, Jordan Pischimariov, Stefan Schreiber, Inga Vater, Lydia Hopp, David Langenberge & Maciej Rosolowski
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Summary:Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that underpin this disease how alterations on different cellular levels cooperate in deregulating key pathways and complexes.
Item Description:Gesehen am 24.05.2019
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-08578-3

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