Lack of an association between the functional polymorphism TREM-1 rs2234237 and the clinical course of sepsis among critically Ill caucasian patients—a monocentric prospective genetic association study
Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
3 March 2019
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| In: |
Journal of Clinical Medicine
Year: 2019, Volume: 8, Issue: 3, Pages: 1-11 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm8030301 |
| Online Access: | Verlag, Volltext: https://doi.org/10.3390/jcm8030301 Verlag, Volltext: https://www.mdpi.com/2077-0383/8/3/301 
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| Author Notes: | Julius Runzheimer, Caspar Mewes, Benedikt Büttner, José Hinz, Aron-Frederik Popov, Michael Ghadimi, Katalin Kristof, Tim Beissbarth, Joel Schamroth, Mladen Tzvetkov, Bastian Schmack, Michael Quintel, Ingo Bergmann and Ashham Mansur |
| Summary: | Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for the triggering receptor expressed on myeloid cells 1, which is part of the pro-inflammatory response of the immune system. This study aimed to determine whether the functional TREM-1 rs2234237 single nucleotide polymorphism was associated with mortality in a cohort of 649 Caucasian patients with sepsis. The 90-day mortality rate was the primary outcome, and disease severity and microbiological findings were analyzed as secondary endpoints. TREM-1 rs2234237 TT homozygous patients were compared to A-allele carriers for this purpose. Kaplan–Meier survival analysis revealed no association between the clinically relevant TREM-1 rs2234237 single nucleotide polymorphism and the 90-day or 28-day survival rate in this group of septic patients. In addition, the performed analyses of disease severity and the microbiological findings did not show significant differences between the TREM-1 rs2234237 genotypes. The TREM-1 rs2234237 genotype was not significantly associated with sepsis mortality and sepsis disease severity. Therefore, it was not a valuable prognostic marker for the survival of septic patients in the studied cohort. |
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| Item Description: | Gesehen am 28.05.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm8030301 |