Children of mentally III parents at risk evaluation (COMPARE): design and methods of a randomized controlled multicenter study - part I
Objectives: Mental disorders are frequent, associated with disability-adjusted life years, societal and economic costs. Children of parents with a mental illness (COPMI) are at an increased risk to develop disorders themselves. The transgenerational transmission of mental disorders has been conceptu...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 March 2019
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| In: |
Frontiers in psychiatry
Year: 2019, Volume: 10 |
| ISSN: | 1664-0640 |
| DOI: | 10.3389/fpsyt.2019.00128 |
| Online Access: | Verlag, Volltext: https://doi.org/10.3389/fpsyt.2019.00128 Verlag, Volltext: https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00128/full 
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| Author Notes: | Hanna Christiansen, Corinna Reck, Anna-Lena Zietlow, Kathleen Otto, Ricarda Steinmayr, Linda Wirthwein, Sarah Weigelt, Rudolf Stark, David D. Ebert, Claudia Buntrock, Johannes Krisam, Christina Klose, Meinhard Kieser and Christina Schwenck |
| Summary: | Objectives: Mental disorders are frequent, associated with disability-adjusted life years, societal and economic costs. Children of parents with a mental illness (COPMI) are at an increased risk to develop disorders themselves. The transgenerational transmission of mental disorders has been conceptualized in a model that takes parental and family factors, the social environment (i.e. school, work, social support), parent-child-interaction and possible child outcomes into account. The goal of the “Children of Mentally Ill Parents At Risk Evaluation” (COMPARE) study will thus be twofold: 1) to establish the efficacy and cost-effectivness of a high-quality randomized controlled trial (RCT) with the aim of interrupting the intergenerational transmission of mental disorders in COPMI; 2) to test the components of the trans-generational transmission model of mental disorders. Methods: To implement a randomized controlled trial (RCT: comparison of parental cognitive behavioural therapy/CBT with CBT + Positive Parenting Program) that is flanked by four add-on projects that apply behavioral, psychophysiological, and neuro-imaging methods to examine potential moderators and mediators of risk transmission (projects COMPARE-emotion/-interaction/-work/-school). COMPARE-emotion targets emotion processing and regulation and its impact on the transgenerational disorder transmission; COMPARE-interaction focuses especially on the impact of maternal comorbid diagnoses of depression and anxiety disorders and will concentrate on different pathways of the impact of maternal disorders on socio-emotional and cognitive infant development, such as parent-infant interaction and the infant's stress regulation skills. COMPARE-work analyzes the transmission of strains a person experiences in one area of life to another (i. e. from family to work; spill-over), and how stress and strain are transmitted between indivuduals (i. e. from parent to child; cross-over). COMPARE-school focuses on the psychosocial adjustment, school performance, and subjective well-being in COPMI compared to an adequate control group of healthy children. Results: This study protocol reports on the interdisciplinary approach of COMPARE testing the model of the transgenerational transmission of mental disorders. Conclusion: The combination of applied basic with clinical research will facilitate the examination of specific risk transmission mechanisms, promotion, dissemination and implementation of results into a highly important but largely neglected field. |
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| Item Description: | Gesehen am 28.05.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1664-0640 |
| DOI: | 10.3389/fpsyt.2019.00128 |