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EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

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Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. Despite the relevance of these pathophysiological mechanisms for disease progression and ou...

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Main Authors: Ernst, Anne-Sophie (Author) , Böhler, Laura-Inés (Author) , Hertle, Anna M. (Author) , Hoffmann, Angelika (Author) , Heiland, Sabine (Author) , Sticht, Carsten (Author) , Bendszus, Martin (Author) , Hecker, Markus (Author) , Bading, Hilmar (Author) , Marti, Hugo (Author) , Korff, Thomas (Author) , Kunze, Reiner (Author)
Format: Article (Journal)
Language:English
Published: 5 February 2019
In: Acta Neuropathologica Communications
Year: 2019, Volume: 7, Pages: 1-23
ISSN:2051-5960
DOI:10.1186/s40478-019-0669-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40478-019-0669-7
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Author Notes:Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti, Thomas Korff and Reiner Kunze
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Summary:Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. Despite the relevance of these pathophysiological mechanisms for disease progression and outcome, molecular determinants controlling the onset of these processes are only partially understood. In this context, our study intended to investigate the functional role of EphB2, a receptor tyrosine kinase that is crucial for synapse function and binds to membrane-associated ephrin-B ligands.
Item Description:Gesehen am 28.05.2019
Physical Description:Online Resource
ISSN:2051-5960
DOI:10.1186/s40478-019-0669-7

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