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EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

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Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. Despite the relevance of these pathophysiological mechanisms for disease progression and ou...

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Main Authors: Ernst, Anne-Sophie (Author) , Böhler, Laura-Inés (Author) , Hertle, Anna M. (Author) , Hoffmann, Angelika (Author) , Heiland, Sabine (Author) , Sticht, Carsten (Author) , Bendszus, Martin (Author) , Hecker, Markus (Author) , Bading, Hilmar (Author) , Marti, Hugo (Author) , Korff, Thomas (Author) , Kunze, Reiner (Author)
Format: Article (Journal)
Language:English
Published: 5 February 2019
In: Acta Neuropathologica Communications
Year: 2019, Volume: 7, Pages: 1-23
ISSN:2051-5960
DOI:10.1186/s40478-019-0669-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40478-019-0669-7
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Author Notes:Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti, Thomas Korff and Reiner Kunze
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EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke by Ernst, Anne-Sophie (Author) , Böhler, Laura-Inés (Author) , Hertle, Anna M. (Author) , Hoffmann, Angelika (Author) , Heiland, Sabine (Author) , Sticht, Carsten (Author) , Bendszus, Martin (Author) , Hecker, Markus (Author) , Bading, Hilmar (Author) , Marti, Hugo (Author) , Korff, Thomas (Author) , Kunze, Reiner (Author) ,

BioMed Central 2019 Universitätsbibliothek Heidelberg 2019

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