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Aberrant ICOS+-T cell differentiation in women with spontaneous preterm labor

Problem Recent studies revealed appropriate differentiation of recent thymic emigrant (RTE)-regulatory T cells (Tregs) to be crucial for maintaining healthy pregnancy. Currently, the role of responder T cells (Tresps) is not known. Method of study Six-color flow cytometric analysis was used to detec...

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Main Authors: Kälble, Florian (Author) , Mai, Charlotte (Author) , Wagner, Miriam (Author) , Schober, Linda (Author) , Schaier, Matthias (Author) , Zeier, Martin (Author) , Spratte, Julia (Author) , Fluhr, Herbert (Author) , Steinborn-Kröhl, Andrea (Author)
Format: Article (Journal)
Language:English
Published: 21 September 2016
In: American journal of reproductive immunology
Year: 2016, Volume: 76, Issue: 5, Pages: 415-425
ISSN:1600-0897
DOI:10.1111/aji.12565
Online Access:Verlag, Volltext: https://doi.org/10.1111/aji.12565
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.12565
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Author Notes:Florian Kälble, Charlotte Mai, Miriam Wagner, Linda Schober, Matthias Schaier, Martin Zeier, Julia Spratte, Herbert Fluhr, Andrea Steinborn
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Summary:Problem Recent studies revealed appropriate differentiation of recent thymic emigrant (RTE)-regulatory T cells (Tregs) to be crucial for maintaining healthy pregnancy. Currently, the role of responder T cells (Tresps) is not known. Method of study Six-color flow cytometric analysis was used to detect differences in the differentiation of highly proliferative inducible co-stimulatory (ICOS)+-RTE-Tregs/Tresps and apoptosis-sensitive ICOS−-RTE-Tregs/Tresps into mature naïve (MN)-, CD31+-memory and CD31−-memory Tregs/Tresps in women with spontaneous preterm labor (sPL) compared to healthy pregnancy. Results Healthy pregnancy was characterized by an increased differentiation of ICOS+- and ICOS−-RTE-Tregs, as well as ICOS+-RTE-Tresps via CD31+-memory Tregs/Tresps into CD31−-memory Tregs/Tresps. Women with sPL showed an early interruption of RTE-Treg/Tresp differentiation. Instead, ICOS+-MN-Tresps and partly ICOS−-MN-Tregs differentiated into CD31−-memory Tregs/Tresps, causing a significant reduction of both ICOS+-Tregs and ICOS+-Tresps, but an increase of ICOS−-Tresps within total CD4+-T-helper cells. Conclusion Aberrant differentiation of ICOS+-T cells is associated with sPL.
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Gesehen am 29.05.2019
Physical Description:Online Resource
ISSN:1600-0897
DOI:10.1111/aji.12565

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