Probing molecular forces in multi-component physiological membranes
Biological membranes are remarkably heterogeneous, composed of diverse lipid mixtures with distinct chemical structure and composition. By combining molecular dynamics simulations and the newly developed Lipid-Force Distribution Analysis (L-FDA), we explore force transmission in complex multi-compon...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Physical chemistry, chemical physics
Year: 2017, Volume: 20, Issue: 4, Pages: 2155-2161 |
| ISSN: | 1463-9084 |
| DOI: | 10.1039/C7CP05981G |
| Online Access: | Verlag, Volltext: https://doi.org/10.1039/C7CP05981G Verlag, Volltext: https://pubs.rsc.org/en/content/articlelanding/2018/cp/c7cp05981g 
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| Author Notes: | Arjun Ray, Frauke Gräter and Lipi Thukral |
| Summary: | Biological membranes are remarkably heterogeneous, composed of diverse lipid mixtures with distinct chemical structure and composition. By combining molecular dynamics simulations and the newly developed Lipid-Force Distribution Analysis (L-FDA), we explore force transmission in complex multi-component membrane models mimicking eukaryotic organelles. We found that the chemical-moiety based segmentation at membrane interfaces revealed a distinctive distribution of bonded and non-bonded forces in diverse membrane environment. Our molecular stress analysis could have far-reaching implications in describing the relationship between membrane mechanical properties and functional states of chemically distinct lipids. |
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| Item Description: | First published on 27 Nov 2017 Gesehen am 29.05.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1463-9084 |
| DOI: | 10.1039/C7CP05981G |