Biocompatible peritoneal dialysis: the target is still way off
Peritoneal dialysis (PD) is a cost-effective, home based therapy for patients with end stage renal disease achieving similar outcome as compared to hemodialysis. Still, a minority of patients only receives PD. To a significant extend, this discrepancy is explained by major limitations regarding PD e...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
07 January 2019
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| In: |
Frontiers in physiology
Year: 2019, Volume: 9 |
| ISSN: | 1664-042X |
| DOI: | 10.3389/fphys.2018.01853 |
| Online Access: | Verlag, Volltext: https://doi.org/10.3389/fphys.2018.01853 Verlag, Volltext: https://www.frontiersin.org/articles/10.3389/fphys.2018.01853/full 
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| Author Notes: | Maria Bartosova and Claus Peter Schmitt |
| Summary: | Peritoneal dialysis (PD) is a cost-effective, home based therapy for patients with end stage renal disease achieving similar outcome as compared to hemodialysis. Still, a minority of patients only receives PD. To a significant extend, this discrepancy is explained by major limitations regarding PD efficiency and sustainability. Due to highly unphysiological composition of PD fluids, the peritoneal membrane undergoes rapid morphological and long-term functional alterations which limit the treatment and contribute to adverse patient outcome. This review is focused on the peritoneal membrane ultrastructure and its transformation in patients with kidney disease and chronic PD, underlying molecular mechanisms and potential systemic sequelae. Current knowledge on the impact of conventional and second generation PD fluids is described; novel strategies and innovative PD fluid types are discussed. |
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| Item Description: | Gesehen am 10.06.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1664-042X |
| DOI: | 10.3389/fphys.2018.01853 |