IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney
BACKGROUND/AIM: Chronic inflammation in end-stage kidney is associated with the development of pre-neoplastic lesions and renal cell tumors. The aim of this study was to clarify the role of the inflammatory microenvironment in this process. - MATERIALS AND METHODS: We used representative microscopic...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
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| In: |
Anticancer research
Year: 2019, Volume: 39, Issue: 4, Pages: 1869-1874 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.13294 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.21873/anticanres.13294
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| Author Notes: | Lehel Peterfi, Maria V. Yusenko, Gyula Kovacs |
| Summary: | BACKGROUND/AIM: Chronic inflammation in end-stage kidney is associated with the development of pre-neoplastic lesions and renal cell tumors. The aim of this study was to clarify the role of the inflammatory microenvironment in this process. - MATERIALS AND METHODS: We used representative microscopic slides from 11 end stage-kidneys containing pre-neoplastic lesions and tumors and applied immunohistochemistry to detect IL-6, SAA1 and LBP expression. We also applied array-based comparative genomic hybridization (CGH) analysis to detect genomic changes in tumor cells. - RESULTS: We identified strong expression of IL6, LBP and SAA1 in activated stromal fibroblasts, in proliferating epithelial and tumor cells. Array CGH detected unusual genomic changes in tumor cells. - CONCLUSION: Our data indicate that expression of IL6, acute phase protein SAA1 and LBP maintain a long-lasting inflammatory microenvironment that leads to remodeling of end-stage kidneys and the development of unique types of renal cell tumors. |
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| Item Description: | Gesehen am 06.06.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.13294 |