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Cortactin expression: association with disease progression and survival in oral squamous cell carcinoma

Background Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival. Methods CTTN-dependent invasion was performed using...

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Main Authors: Horn, Dominik (Author) , Dyckhoff, Gerhard (Author) , Fuchs, Jennifer (Author) , Grabe, Niels (Author) , Weichert, Wilko (Author) , Herpel, Esther (Author) , Herold-Mende, Christel (Author) , Lichter, Peter (Author) , Hoffmann, Jürgen (Author) , Heß, Jochen (Author) , Freier, Kolja (Author)
Format: Article (Journal)
Language:English
Published: 20 November 2018
In: Head & neck
Year: 2018, Volume: 40, Issue: 12, Pages: 2685-2694
ISSN:1097-0347
DOI:10.1002/hed.25515
Online Access:Verlag, Volltext: https://doi.org/10.1002/hed.25515
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25515
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Author Notes:Dominik Horn, Madeleine Gross, Gerhard Dyckhoff, Jennifer Fuchs, Niels Grabe, Wilko Weichert, Esther Herpel, Christel Herold‐Mende, Peter Lichter, Jürgen Hoffmann, Jochen Hess, Kolja Freier
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Summary:Background Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival. Methods CTTN-dependent invasion was performed using migration assay in human papillomavirus-negative head and neck squamous cell carcinoma (HNSCC) cells. Cortactin protein analysis in tissue microarrays was used for correlation with clinical parameters, as well as for survival analysis. Gene expression profiling in HNSCC cells was performed to unreveal CTTN signaling. Results Knockdown of CTTN in HNSCC cells showed less invasion in vitro. Gene expression profiling showed various deregulated genes known to be involved in progression. We confirmed the link between CTTN overexpression and progression in a large clinical cohort. High expression was associated with worse overall and progression-free survival. Conclusions We propose CTTN for managing OSCC in terms of adjuvant therapy and aftercare. Furthermore, our study reveals new potential targets in CTTN signaling for individualized OSCC therapy.
Item Description:Gesehen am 13.06.2019
Physical Description:Online Resource
ISSN:1097-0347
DOI:10.1002/hed.25515

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