Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation
Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by phosphatidylserine during myotube formation.
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 May 2018
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| In: |
Nature Communications
Year: 2018, Volume: 9, Pages: 2049 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-04436-w |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41467-018-04436-w Verlag, Volltext: https://www.nature.com/articles/s41467-018-04436-w 
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| Author Notes: | Masaki Tsuchiya, Yuji Hara, Masaki Okuda, Karin Itoh, Ryotaro Nishioka, Akifumi Shiomi, Kohjiro Nagao, Masayuki Mori, Yasuo Mori, Junichi Ikenouchi, Ryo Suzuki, Motomu Tanaka, Tomohiko Ohwada, Junken Aoki, Motoi Kanagawa, Tatsushi Toda, Yosuke Nagata, Ryoichi Matsuda, Yasunori Takayama, Makoto Tominaga and Masato Umeda |
| Summary: | Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by phosphatidylserine during myotube formation. |
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| Item Description: | Gesehen am 13.06.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-04436-w |