Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice
Rationale: Drug-induced sensitization in the mesocorticolimbic systems is thought to play an important role in certain aspects of drug addiction, including the involvement of drug-associated cues and environments in mediating drug-seeking behaviors. Our previous studies have identified the significa...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 January 2016
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| In: |
Psychopharmacology
Year: 2016, Volume: 233, Issue: 7, Pages: 1147-1155 |
| ISSN: | 1432-2072 |
| DOI: | 10.1007/s00213-015-4197-2 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1007/s00213-015-4197-2
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| Author Notes: | Wang-Jun Qin, Yan-Ting Wang, Peng-Mei Li, Xiao-Xing Wang, Jun-Xu Li, Hamid R. Noori, Rick E. Bernardi, Jian-Hui Liang, Xiang-Lin Zhang |
| Summary: | Rationale: Drug-induced sensitization in the mesocorticolimbic systems is thought to play an important role in certain aspects of drug addiction, including the involvement of drug-associated cues and environments in mediating drug-seeking behaviors. Our previous studies have identified the significance of heat shock protein 70 (Hsp70) in the development of a single morphine exposure-induced behavioral sensitization. Objectives: The present study expands upon these findings by investigating the effect of environment on the expression of behavioral sensitization induced by a single morphine exposure, and the potential involvement of Hsp70 protein levels in these effects. Methods: Mice were pretreated with a single morphine injection in test chambers (morphine-paired) or home cages (morphine-unpaired) on day 1 and challenged on day 2 or 8, in test chambers. Hsp70 expression in the nucleus accumbens (NAc) was analyzed after the challenge. Results: The expression of single morphine exposure-induced behavioral sensitization was accompanied by a significant increase in Hsp70 expression in NAc. In contrast, the unpaired morphine-treated group failed to exhibit behavioral sensitization or higher Hsp70 expression. Additionally, by adding a habituation process prior to the challenge, we demonstrated that conditioned hyperactivity, which was not accompanied by an increased expression of Hsp70, is not essential for behavioral sensitization. Conclusions: Behavioral sensitization induced by a single morphine exposure in mice exhibits context and time dependency, with environmental context likely functioning via an inhibitory conditioning mechanism. Furthermore, alterations in Hsp70 expression in the NAc may represent a neurobiological sensitization mechanism mediating context- and time-dependent behavioral sensitization. |
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| Item Description: | Gesehen am 13.06.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1432-2072 |
| DOI: | 10.1007/s00213-015-4197-2 |