Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to identify potential novel prostate cancer risk loci a...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
04 October 2018
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| In: |
Nature Communications
Year: 2018, Jahrgang: 9 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-06302-1 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/s41467-018-06302-1 Verlag, Volltext: https://www.nature.com/articles/s41467-018-06302-1 
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| Verfasserangaben: | Nicholas Mancuso, Simon Gayther, Alexander Gusev, Wei Zheng, Kathryn L. Penney, the PRACTICAL consortium#, Zsofia Kote-Jarai, Rosalind Eeles ,Matthew Freedman, Christopher Haiman & Bogdan Pasaniuc |
| Zusammenfassung: | Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to identify potential novel prostate cancer risk loci and possible risk mechanisms. |
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| Beschreibung: | The PRACTICAL consortium: Hermann Brenner [und weitere] Hermann Brenner ist Mitglied des PRACTICAL consortium Gesehen am 05.07.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-06302-1 |