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MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently induce stem cell plasticity in colorectal cancer.

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Bibliographic Details
Main Authors: Zhan, Tianzuo (Author) , Ambrosi, Giulia (Author) , Wandmacher, Anna Maxi (Author) , Betge, Johannes (Author) , Hinsenkamp, Isabel (Author) , Bamberg, Leonhard Valentin (Author) , Heßling, Bernd (Author) , Müller-Decker, Karin (Author) , Burgermeister, Elke (Author) , Ebert, Matthias (Author) , Boutros, Michael (Author)
Format: Article (Journal)
Language:English
Published: 16 May 2019
In: Nature Communications
Year: 2019, Volume: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-09898-0
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-019-09898-0
Verlag, Volltext: https://www.nature.com/articles/s41467-019-09898-0
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Author Notes:Tianzuo Zhan, Giulia Ambrosi, Anna Maxi Wandmacher, Benedikt Rauscher, Johannes Betge, Niklas Rindtorff, Ragna S. Häussler, Isabel Hinsenkamp, Leonhard Bamberg, Bernd Hessling, Karin Müller-Decker, Gerrit Erdmann, Elke Burgermeister, Matthias P. Ebert & Michael Boutros
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Summary:Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently induce stem cell plasticity in colorectal cancer.
Item Description:Tianzuo Zhan, Giulia Ambrosi and Anna Maxi Wandmacher contributed equally
Gesehen am 28.06.2019
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-09898-0

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