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Plasma parathyroid hormone is independently related to nocturnal blood pressure in hypertensive patients: the Styrian Hypertension Study

High parathyroid hormone (PTH) has been linked with high blood pressure (BP), but the relationship with 24-hour ambulatory blood pressure monitoring is largely unknown. The authors therefore analyzed cross-sectional data of 292 hypertensive patients participating in the Styrian Hypertension Study (m...

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Bibliographic Details
Main Authors: Verheyen, Nicolas (Author) , März, Winfried (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: The journal of clinical hypertension
Year: 2015, Volume: 18, Issue: 6, Pages: 543-550
ISSN:1751-7176
DOI:10.1111/jch.12710
Online Access:Verlag, Volltext: https://doi.org/10.1111/jch.12710
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jch.12710
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Author Notes:Nicolas D. Verheyen MD; Katharina Kienreich MD; Martin Gaksch MD; Adriana J. van Ballegooijen PhD; Martin R. Grübler MD; Briain Ó. Hartaigh PhD; Johannes Schmid MD; Astrid Fahrleitner‐Pammer MD; Elisabeth Kraigher‐Krainer MD; Caterina Colantonio MD; Evgeny Belyavskiy MD; Gerlies Treiber MD, PhD; Cristiana Catena MD; Helmut Brussee MD, PhD; Burkert Pieske MD, PhD; Winfried März MD, PhD; Andreas Tomaschitz MD; Stefan Pilz MD, PhD
Description
Summary:High parathyroid hormone (PTH) has been linked with high blood pressure (BP), but the relationship with 24-hour ambulatory blood pressure monitoring is largely unknown. The authors therefore analyzed cross-sectional data of 292 hypertensive patients participating in the Styrian Hypertension Study (mean age, 61±11 years; 53% women). Median plasma PTH (interquartile range) determined after an overnight fast was 49 pg/mL (39-61), mean daytime BP was 131/80±12/9 mm Hg, and mean nocturnal BP was 115/67±14/9 mm Hg. In multivariate regression analyses adjusted for BP and PTH-modifying parameters, PTH was significantly related to nocturnal systolic and diastolic BP (adjusted β-coefficient 0.140 [P=.03] and 0.175 [P<.01], respectively). PTH was not correlated with daytime BP readings. These data suggest a direct interrelationship between PTH and nocturnal BP regulation. Whether lowering high PTH concentrations reduces the burden of high nocturnal BP remains to be shown in future studies.
Item Description:Gesehen am 01.07.2019
First published: 12 October 2015
Physical Description:Online Resource
ISSN:1751-7176
DOI:10.1111/jch.12710

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