Bcl10-controlled malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg sup...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
28 May 2019
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| In: |
Nature Communications
Year: 2019, Volume: 10 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-10203-2 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41467-019-10203-2 Verlag, Volltext: https://www.nature.com/articles/s41467-019-10203-2 
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| Author Notes: | Marc Rosenbaum, Andreas Gewies, Konstanze Pechloff, Christoph Heuser, Thomas Engleitner, Torben Gehring, Lara Hartjes, Sabrina Krebs, Daniel Krappmann, Mark Kriegsmann, Wilko Weichert, Roland Rad, Christian Kurts, Jürgen Ruland |
| Summary: | The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg suppressive activity in a MALT1 paracaspase-dependent manner. |
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| Item Description: | Gesehen am 04.07.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-10203-2 |