TelomereHunter: in silico estimation of telomere content and composition from cancer genomes
Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrations in telomere composition. To retrieve these telomere chara...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
28 May 2019
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| In: |
BMC bioinformatics
Year: 2019, Volume: 20 |
| ISSN: | 1471-2105 |
| DOI: | 10.1186/s12859-019-2851-0 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1186/s12859-019-2851-0 |
| Author Notes: | Lars Feuerbach, Lina Sieverling, Katharina I. Deeg, Philip Ginsbach, Barbara Hutter, Ivo Buchhalter, Paul A. Northcott, Sadaf S. Mughal, Priya Chudasama, Hanno Glimm, Claudia Scholl, Peter Lichter, Stefan Fröhling, Stefan M. Pfister, David T.W. Jones, Karsten Rippe, Benedikt Brors |
| Summary: | Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrations in telomere composition. To retrieve these telomere characteristics from high-throughput sequencing data the available computational approaches need to be extended and optimized to fully exploit the information provided by large scale cancer genome data sets. |
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| Item Description: | Gesehen am 09.07.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1471-2105 |
| DOI: | 10.1186/s12859-019-2851-0 |